Subclinical cardiac dysfunction in children with coeliac disease: Is the gluten free diet effective
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Date
2012
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Abstract
Objectives. The aim of this study is to investigate the effects of coeliac disease on cardiac function in children using conventional
transthoracic echocardiography (TTE) and tissue Doppler echocardiography (TDE). Methods. Coeliac disease patients were
evaluated in two different groups based on serum endomysial antibody (EmA) titers (EmA (+) and EmA (−)), and the data
obtained by conventional and TDE studies were compared between the patient groups and healthy controls. Results. There was
no significant difference between EmA (+) and EmA (−) groups in terms of the conventional TTE parameters, including ejection
fraction (EF), fractional shortening (FS), and left ventricle end diastolic diameter (LVEDD), that show the left ventricular systolic
function (P = 0.727, P = 0.317, P = 0.118). TDE showed a significant difference in left ventricle (LV) isovolumic relaxation
time (LV IVRT) and LV myocardial performance index (LV MPI) parameters between EmA (+) and EmA (−) patient groups
(P < 0.0001). Conclusion. The measurement of LV MPI and LV IVRT parameters by TDE would be beneficial in early determination
of the cardiac involvement and establishing appropriate treatment and followup of patients with coeliac disease as well as in making
distinction between EmA (+) and EmA (−) patients.
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Keywords
Celiac disease, Cardiac dysfunction, Children