Preliminary evaluation of rat kidney aldose reductase inhibitory activity of 2-phenylindole derivatives: Affiliation to antioxidant activity

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dc.contributor.authorSüzen, Sibel
dc.contributor.departmentEğitim Bilimleri Fakültesitr_TR
dc.contributor.otherEvci̇Men, Net Daş
dc.contributor.otherVarol, Pınar
dc.contributor.otherSarikaya, Mutlu
dc.date.accessioned2020-03-17T13:50:08Z
dc.date.available2020-03-17T13:50:08Z
dc.date.issued2007
dc.description.abstractDiabetic complications including nephropathy, neuropathy, and cataract are leading causes of end-stage renal diseases and neurological disorders. Aldose reductase (AR), the rate-limiting enzyme of the polyol pathway, catalyzes the reduction of glucose to sorbitol via NADPH. Excessive accumulation of intracellular sorbitol found in various tissues of diabetic animals and in cells cultured under high glucose conditions has been proposed to be an important factor for the pathogenesis of diabetic complications. Indole ring-containing AR inhibitors have received considerable attention as potential treatments for diabetic complications. However, these agents have not achieved worldwide use because of limited efficacy or unacceptable adverse effects. In this study, a series of 2-phenylindole derivatives were evaluated via an in vitro spectrophotometric assay for their ability to inhibit rat kidney AR. In addition, the antioxidant and AR inhibitory activities of the compounds under study were compared.tr_TR
dc.description.indexwos
dc.description.indexScopus
dc.identifier.endpage118tr_TR
dc.identifier.issue3tr_TR
dc.identifier.startpage112tr_TR
dc.identifier.urihttps://doi.org/10.1007/s00044-007-9014-ytr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70711
dc.identifier.volume16tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1007/s00044-007-9014-ytr_TR
dc.relation.journalMedicinal Chemistry Researchtr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subject2-phenylindoletr_TR
dc.subjectAldose reductasetr_TR
dc.subjectAntioxidanttr_TR
dc.subjectDiabetes mellitusInhibitorytr_TR
dc.titlePreliminary evaluation of rat kidney aldose reductase inhibitory activity of 2-phenylindole derivatives: Affiliation to antioxidant activitytr_TR
dc.typeArticletr_TR

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