Variability of anti-human transglutaminase testing in celiac disease across Mediterranean countries
| dc.contributor.author | Kansu, Aydan | |
| dc.contributor.department | Tıp Fakültesi | tr_TR |
| dc.date.accessioned | 2020-02-18T22:30:14Z | |
| dc.date.available | 2020-02-18T22:30:14Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | AIM To verify the precision and accuracy of transglutaminase antibodies (TGA) assays across Mediterranean countries. METHODS This study involved 8 referral centres for celiac disease (CD) in 7 Mediterranean countries. A central laboratory prepared 8 kits of 7 blinded and randomized serum samples, with a titrated amount of Human TGA IgA. Each sample was analysed three times on three different days, with each centre running a total of 21 tests. The results were included in a blindly coded report form, which was sent to the coordinator centre. The coordinator estimated the mean coefficient of Variation (CoVar = σ/μ), the mean accuracy (Accur = Vobserved -Vreal) and the mean percent variation (Var% = [(Vobserved -Vreal)/Vreal] × 100). RESULTS The analysis showed that 79.17% of the mean variation fell between -25% and +25% of the expected value, with the accuracy and precision progressively increasing with higher titres of TGA. From values 1.25 times greater than the normal cut-off, the measurements were highly reliable. CONCLUSION TGA estimation is a crucial step for the diagnosis of CD; given its accuracy and precision, clinicians could be confident in establishing a diagnosis. © The Author(s) 2017. | tr_TR |
| dc.description.index | Wos | |
| dc.description.index | Scopus | |
| dc.identifier.endpage | 4443 | tr_TR |
| dc.identifier.issn/e-issn | 1007-9327 | |
| dc.identifier.issue | 24 | tr_TR |
| dc.identifier.startpage | 4437 | tr_TR |
| dc.identifier.uri | https://doi.org/10.3748/wjg.v23.i24.4437 | tr_TR |
| dc.identifier.uri | http://hdl.handle.net/20.500.12575/69819 | |
| dc.identifier.volume | 23 | tr_TR |
| dc.language.iso | en | tr_TR |
| dc.relation.isversionof | 10.3748/wjg.v23.i24.4437 | tr_TR |
| dc.relation.journal | World Journal of Gastroenterology | tr_TR |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | tr_TR |
| dc.rights | * | |
| dc.rights.uri | http://creativecommons.org/publicdomain/zero/1.0/ | * |
| dc.title | Variability of anti-human transglutaminase testing in celiac disease across Mediterranean countries | tr_TR |
| dc.type | Article | tr_TR |