Serum neuron-specific enolase, a marker of neuronal injury, increases after catheter ablation of atrial fibrillation

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dc.contributor.authorAcibuca, Aynur
dc.contributor.departmentTıp Fakültesitr_TR
dc.date.accessioned2020-12-04T09:02:42Z
dc.date.available2020-12-04T09:02:42Z
dc.date.issued2018
dc.description.abstractObjective: Catheter ablation of atrial fibrillation (AF) can lead to thromboembolic complications, especially stroke. We measured the periprocedural serum neuron-specific enolase (NSE) level, which is a biomarker of neuronal injury, after ablation of AF. Methods: Forty-three patients with paroxysmal AF were prospectively enrolled before radiofrequency ablation. A neurological examination was performed before and after the procedure. The serum NSE level was determined before and at the end of the procedure and at 2, 24, and 48 h after the procedure. Results: No patients developed new neurological deficits. However, the median (interquartile range) NSE level increased after ablation from 6.7 (3.87) ng/mL at baseline to 11.48 (5.3) ng/mL at 24 h postoperatively. The NSE level exceed the upper reference limit of normal (17 ng/mL) in 14 patients (33%), and these patients were found to have a larger left atrium. Conclusions: Serum NSE increased in most of the patients undergoing ablation for AF, and it exceeded the normal limit in one-third of the patients. Although NSE is a biomarker of neuronal injury, the clinical importance of this increase after AF ablation and its relationship with the left atrial diameter should be evaluated in a longitudinal study.tr_TR
dc.description.indexPubmed
dc.identifier.endpage4526tr_TR
dc.identifier.issue11tr_TR
dc.identifier.startpage4518tr_TR
dc.identifier.urihttps://doi.org/10.1177/0300060518767768tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/72529
dc.identifier.volume46tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.1177/0300060518767768tr_TR
dc.relation.journalJ Int Med Res .tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectAtrial fibrillationtr_TR
dc.subjectcatheter ablationtr_TR
dc.subjectcerebral embolismtr_TR
dc.titleSerum neuron-specific enolase, a marker of neuronal injury, increases after catheter ablation of atrial fibrillationtr_TR
dc.typeArticletr_TR

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